More Daily Activity Linked to More Gray Matter in Older Adults’ Brains
Higher levels of everyday physical activity, such as house cleaning, walking a dog, and gardening, are associated with more gray matter in the brains of older adults, according to a new study.
The gray matter in the brain includes regions responsible for controlling muscle movement, experiencing the senses, thinking and feeling, memory and speech and more. The volume of gray matter is a measure of brain health, but the amount of gray matter in the brain often begins to decrease in late adulthood, even before symptoms of cognitive dysfunction appear, noted researchers at Rush University Medical Center in Chicago.
“More gray matter is associated with better cognitive function, while decreases in gray matter are associated with Alzheimer’s disease and other related dementias,” said Shannon Halloway, Ph.D., the study’s lead author and the Kellogg/Golden Lamp Society Postdoctoral Fellow in the Rush University College of Nursing. “A healthy lifestyle, such as participating in lifestyle physical activity, is beneficial for brain health, and may help lessen gray matter atrophy.”
The study measured the levels of lifestyle physical activity by 262 older adults in Rush’s Memory and Aging Project, an ongoing epidemiological cohort study. Participants are recruited from retirement communities and subsidized housing facilities in and around Chicago to participate in annual clinical evaluations and magnetic resonance imaging (MRI) scans, and to donate their brains and other parts of their bodies for research after their deaths.
Participants in the lifestyle study wore a non-invasive device called an accelerometer continuously for seven to 10 days. The goal was to accurately measure the frequency, duration, and intensity of a participant’s activities over that time, the researchers explained.
Lifestyle physical activity is “more realistic for older adults” than a structured exercise program that might require them to go to a gym, according to Halloway.
“Accessibility becomes an issue as one ages,” she said. “Transportation can be a problem. Gym settings can be intimidating for any individual, but especially so for older adults.”
The use of accelerometers was only one of the ways in which this analysis differed from some other investigations of the health of older people, according to Halloway. Most research that explores the effects of exercise relies on questionnaires, which ask participants to “self-report” their levels of activity, she noted.
The problem with questionnaires is that “sometimes, we get really inaccurate reports of activity,” she said. “People commonly over-estimate, and on the flip side, some underestimate the lifestyle activity they’re getting from things they don’t consider exercise, like household chores, for example.”
Another departure in Halloway’s study from others was the opportunity she had to assess the effects of exercise on individuals older than 80. In fact, the mean age in this study was 81 years, compared with 70 years for other studies Halloway used as a reference.
“One great strength of the Rush Alzheimer’s Disease Center is its amazing ability to follow up with participants, and its high retention rates of participants,” she said.
As a result, the Memory and Aging Project captures a number of participants in that older age group, she explained.
However, no one was included in Halloway’s analysis who had a diagnosis or symptoms of dementia, or even mild cognitive impairment; a history of brain surgery; or brain abnormalities such as tumors, as seen on MRIs.
The study compared gray matter volumes as seen in participants’ MRIs with readings from the accelerometers and other data, which all were obtained during the same year. Halloway’s analysis found the association between participants’ actual physical activity and gray matter volumes remained after controlling for age, gender, education levels, body mass index, and symptoms of depression.
All of these are associated with lower levels of gray matter in the brain.
“Our daily lifestyle physical activities are supportive of brain health, and adults of all ages should continue to try and increase lifestyle physical activity to gain these benefits,” Halloway said.
“Moving forward, our goal is to develop and test behavioral interventions that focus on lifestyle physical activity for older adults at increased risk for cognitive decline due to cardiovascular disease.”
The study was published in The Journal of Gerontology: Psychological Sciences.